Biological Models in Radiopharmaceutical Development


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Skickas inom vardagar specialorder. This book explores the mathematics and biology of the biodistribution of radiopharmaceuticals following their introduction into the body, but does so primarily from a clinical perspective - from the point of view of image interpretation and any associated image-derived quantification.

دریافت: Biological Models in Radiopharmaceutical Development |ایی ایی

All of the equations included in the book relate directly to the biodistribution of radiopharmaceuticals and are clinically useful, either conceptually or because of their value in quantifying a biological parameter, e. The efficacy of every diagnostic and therapeutic nuclear medicine procedure is critically dependent on the biodistribution of the radiopharmaceutical in question over time. This book will enable the reader to gain a sound understanding of the relevant mathematics and biology, and the clinical orientation ensures that it will be of value in enhancing clinical practice.

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Bloggat om The Mathematics and Biology of the Biodis Quantity Add to basket. This item has been added to your basket View basket Checkout. Eckelman and myself in The volume had a focus on the animal models that investigators were using in order to design radiotracers that displayed in vivo selectivity as measured by biodistribution and pharmacokinetic studies.


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A concern in the early days of nuclear medicine was species differences. Often a series of labeled compounds were evaluated in a several different animal models in order to gain confidence that the selected radiotracer would behave appropriately in humans. During the past 12 years there have been remarkable advances in molecular genetics, molecular biology, synthetic radiopharmaceutical chemistry, molecular modeling and visualization, and emission tomography.

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Biological models can now be selected that are better defined in terms of molecular aspects of the disease process. The development of high resolution PET and SPET for clinical applications facilitates the development of new radiopharmaceuticals by the use of models to quantitatively evaluate drug effects, and progression of disease, and hence to arrive at better diagnosis and treatments for animals and humans.

With these advances there is an effective use of biological models, and the refinement of alternatives for the development of new radiophannaceuticals.

Those who have dealt with the problem of finding an appropriate animal model for a certain study will especially appreciate this book. Added to basket. Constantinos Tingerides. Practical Ultrasound. Jane Aly. Chest X-rays for Medical Students. Christopher Clarke. Chest X-Ray Made Easy.

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Biological Models in Radiopharmaceutical Development

Making Sense of Echocardiography. Andrew R.

Clark's Essential Physics in Imaging for Radiographers. Klingensmith has had an interest in the mathematics and biology of radiopharmaceutical localization throughout his career. During his nuclear medicine fellowship he determined the information content of first circulation time-activity curves. More recently he developed the clinically oriented equation for clearance of a radiopharmaceutical from blood into tissue, and the general algorithm for determining whether a physiologic measurement needs to be normalized for body size.

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Biological Models in Radiopharmaceutical Development Biological Models in Radiopharmaceutical Development
Biological Models in Radiopharmaceutical Development Biological Models in Radiopharmaceutical Development
Biological Models in Radiopharmaceutical Development Biological Models in Radiopharmaceutical Development
Biological Models in Radiopharmaceutical Development Biological Models in Radiopharmaceutical Development
Biological Models in Radiopharmaceutical Development Biological Models in Radiopharmaceutical Development
Biological Models in Radiopharmaceutical Development Biological Models in Radiopharmaceutical Development
Biological Models in Radiopharmaceutical Development Biological Models in Radiopharmaceutical Development
Biological Models in Radiopharmaceutical Development Biological Models in Radiopharmaceutical Development

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